MOTS-c 10mg: Mitochondrial Peptide

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA–C) is a naturally occurring mitochondria-derived peptide (MDP) consisting of 16 amino acids. It is studied extensively for its potential roles in metabolic regulation, cellular energy production, stress adaptation, and insulin sensitivity within controlled laboratory research environments.

Research has highlighted MOTS-c’s potential interaction with AMPK-related pathways, glucose regulation models, and cellular resilience mechanisms—making it a valuable molecule for investigations into energy production, endurance, and metabolic homeostasis.

Scientific Background

Unlike most peptides that originate from nuclear DNA, MOTS-C is encoded within mitochondrial DNA. This makes it part of a unique class of signaling molecules known as mitochondria-derived peptides.

Research shows MOTS-C may influence:

• AMPK activation (cellular energy sensor)
• Glucose uptake
• Fatty-acid metabolism
• Stress-response pathways
• Mitochondrial homeostasis

Because mitochondria regulate energy production and cellular resilience, MOTS-C is widely used to explore energy-metabolism pathways.

Research Areas of Interest

All information below is intended strictly for scientific, laboratory, and in-vitro research only.

1. Metabolic Regulation

MOTS-C is studied for its effects on:

• AMPK pathway activation
• Glucose and lipid metabolism
• Cellular energy balance

2. Insulin Sensitivity Models

Preclinical research evaluates potential roles in:

• Enhancing glucose uptake
• Improving insulin signaling in metabolic tissues
• Reducing metabolic stress

3. Mitochondrial Function & Stress Response

MOTS-C may support:

• Cellular adaptation to metabolic stress
• Improved mitochondrial efficiency
• Protection during oxidative stress

4. Exercise & Endurance Research

Some studies explore effects on:

• Muscle energy metabolism
• Fatigue resistance
• Physical performance in animal models

5. Age-Related Cellular Research

Because mitochondria decline with age, MOTS-C is studied in:

• Senescence models
• Longevity pathways
• Age-associated metabolic decline

These findings come from animal and cell-based studies, not validated human clinical outcomes.

Molecular Profile

• Peptide: MOTS-C
• Sequence: MRWQEMGYFYRERKLA (16 amino acids)
• Molecular Weight: ~ 2,309 Da
• Category: Mitochondria-Derived Peptide (MDP)
• Form: Lyophilized powder
• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C
• Protect from light, heat, and moisture
• Reconstituted solutions should be used promptly or stored according to lab protocol
• Avoid repeated freeze-thaw cycles

Each 10ml vial is formulated with 10mg of highly purified (>99%) lyophilized MOTS-c, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.