AICAR 50mg: AMPK activator

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound known for its ability to activate AMPK (AMP-activated protein kinase), a central regulator of cellular energy balance, metabolism, mitochondrial function, and glucose uptake.

Because AMPK is involved in fat-burning, endurance, metabolic health, and cellular stress responses, AICAR is widely used in metabolic, performance, mitochondrial, and endurance-related research models.

Scientific Background

AICAR is an adenosine analog that enters cells and is converted to ZMP (AICA ribotide), which mimics AMP.
This activates AMPK, leading to:

• Increased fatty-acid oxidation

• Increased glucose uptake

• Enhanced mitochondrial activity

• Decreased energy storage pathways (e.g., mTOR inhibition)

• Improved cellular energy efficiency

AMPK activation is a key component of:

• Exercise physiology

• Fasting and caloric restriction pathways

• Mitochondrial biogenesis

• Metabolic stress resistance

These mechanisms make AICAR a powerful research tool in metabolic and performance biology.

Research Areas of Interest

All information below is intended strictly for scientific, laboratory, and in-vitro research only.

1. AMPK Activation Pathways

AICAR is one of the most widely used AMPK activators in research.
Studies explore:

• Cellular energy sensing

• ATP/AMP ratio signaling

• Metabolic adaptation to stress

2. Mitochondrial Function & Biogenesis

Experimental models examine AICAR’s influence on:

• Mitochondrial density

• Oxidative phosphorylation

• Cellular endurance signaling

3. Glucose Uptake & Insulin Sensitivity

AICAR is used to research:

• GLUT4 translocation

• Non-insulin–mediated glucose uptake

• Energy-regulation pathways

4. Endurance & Performance Biology

AICAR is often used to understand:

• Exercise-mimetic molecular pathways

• Fat oxidation during activity

• Enhanced metabolic flexibility

5. Fat Metabolism & Lipid Oxidation

Research focuses on:

• Increased fatty-acid usage

• Reduced lipid storage

• Regulation of metabolic enzymes

All findings come from preclinical, in-vitro, or cell-based research.

Molecular Profile

• Compound: AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide)

• Type: AMPK Activator / Adenosine Analog

• Molecular Formula: C₉H₁₅N₄O₈P

• Molecular Weight: ~338.2 g/mol

• Form: Lyophilized powder (research grade)

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store at –20°C

• Keep dry and protected from heat and light

• Reconstituted solution should be used promptly or stored per lab protocol

• Avoid repeated freeze–thaw cycles

  Each vial is formulated with 10MG of highly purified (>99%) lyophilized AICAR, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.