Adipotide 5mg: Fat-Targetting Peptide

Adipotide (FTPP) is an experimental fat-targeting peptidomimetic that kills white fat cells by starving their blood supply. Adipotide (also known as FTPP) is studied for its potential involvement in fat-targeting pathways, metabolic regulation, and vascular-modulating biological models. Research focuses on how Adipotide may selectively interact with vasculature associated with adipose tissue, making it a key peptide in metabolic and fat-cell signaling studies.

Scientific Background

Adipotide is a hybrid peptide structure that combines:

1. A targeting domain

   • Recognizes prohibitin, a protein expressed on the surface of white adipose tissue vasculature.

2. A pro-apoptotic domain

   • Induces programmed cell death in targeted vascular cells.

This dual mechanism allows researchers to study:

• Reduction of blood supply to adipose tissue

• Adipocyte shrinkage and metabolic remodeling

• Caspase-dependent apoptotic pathways

• Effects of selective adipose vascular disruption

Because adipose tissue depends on robust vasculature for nutrient delivery, Adipotide provides a unique model for examining fat reduction through vascular targeting, rather than hormone- or receptor-mediated pathways.

Research Areas of Interest

All information below is intended strictly for laboratory, scientific, and in-vitro research.

1. Adipose Tissue Biology & Vascular Research

Adipotide is studied for its influence on:

• White adipose vasculature

• Vascular regression and remodeling

• Adipocyte size reduction

• Fat-tissue mass studies

2. Apoptosis & Cell-Cycle Pathways

Researchers explore:

• Caspase-mediated apoptosis

• Selective cell-targeting mechanisms

• Vessel-dependent tissue signaling

3. Metabolic Research Models

Used to evaluate:

• Changes in metabolic rate

• Insulin-related markers (experimental)

• Fat oxidation and nutrient availability

4. Novel Fat-Loss Mechanism Studies

Adipotide provides an alternative to:

• Hormonal fat-loss pathways

• AMPK activation

• β-adrenergic stimulation

• Incretin-based metabolic signaling

Molecular Profile

• Peptide: Adipotide (FTPP)

• Structure: Targeting peptide + pro-apoptotic peptide

• Type: Vascular-targeted research peptide

• Sequence: CKGGRAKDC-GG-D(KLAKLAK)₂

• Length: 26 amino acids (approx.)

• Molecular Weight: ~2,450 Da (varies by manufacturer)

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from heat, moisture, and light

• Use reconstituted peptide promptly or store per laboratory guidelines

• Avoid repeated freeze–thaw cycles

Each 3ml vial is formulated with 5mg of highly purified (>99%) lyophilized Adipotide, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.