GLP-2 Tirz 10mg: Dual-Incretin Receptor Agonist

GLP-2 Tirz is a synthetic dual-incretin receptor agonist engineered to activate both the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual activity has made GLP-2 TZ one of the most studied modern peptides in metabolic, glucose-regulation, and energy-balance research.

It is used exclusively in laboratory settings to examine multi-hormonal metabolic pathways and incretin-based signaling.

Scientific Background

GLP-2 Tirz is a 39-amino-acid peptide modified with a fatty-acid side chain to extend its half-life and enhance receptor engagement. By simultaneously activating GLP-1 and GIP receptors, GLP-2 Tirz allows researchers to study:

Enhanced insulin signaling

Improved glucose control

Appetite and satiety pathways

Energy expenditure

Adipose-tissue metabolic signaling

Hormonal synergy effects

The dual mechanism offers a deeper look into incretin physiology compared to single-pathway GLP-1 analogues like Semaglutide or Liraglutide.

Research Areas of Interest

All information below is intended strictly for laboratory, scientific, and in-vitro research only.

1. Glucose Regulation & Insulin Signaling

GLP-2 Tirz is used in preclinical studies to evaluate:

β-cell responsiveness

Insulin secretion patterns

Postprandial glucose handling

2. Metabolic & Endocrine Pathway Studies

Researchers examine its influence on:

Energy balance

Fat metabolism

Hormonal cross-talk between GLP-1 and GIP pathways

3. Appetite and Satiety Models

Because incretin hormones strongly affect feeding behavior, experiments explore:

Hunger signaling

Fullness/satiety pathways

Caloric-intake modulation

4. Body-Weight & Adipose-Tissue Research

Investigations include:

Lipid mobilization

Adipocyte signaling

Mitochondrial metabolic responses

5. Comparative Incretin Studies

GLP-2 TZ is frequently studied alongside:

Semaglutide (GLP-1)

GLP-3 (GLP-1/GIP/Glucagon triple agonist)

Cagrilintide (amylin analogue)

This helps researchers analyze dual vs. triple agonist effects.

Molecular Profile

Peptide: GLP-2 Tirz

Type: Dual GLP-1/GIP Receptor Agonist

Sequence Length: 39 amino acids (+ fatty-acid modification)

Form: Lyophilized powder

Purity: ≥ 98% (HPLC tested)

Storage & Stability

Store lyophilized peptide at –20°C

Protect from light, moisture, and heat

Reconstituted solutions should be used promptly or stored per laboratory protocol

Avoid repeated freeze-thaw cycles

Each 3 mL vial is formulated with 10 mg of highly purified (>99%) lyophilized GLP-2 Tirz, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.