AOD9604 10mg: Lypolytic Peptide Fragment

AOD-9604 (Advanced Obesity Drug 9604) is a synthetic lipolytic peptide fragment derived from human Growth Hormone (hGH). It consists of the modified 176–191 amino-acid region of hGH, engineered to retain the fat-metabolism and lipolysis-related activity of Growth Hormone without influencing growth pathways associated with IGF-1.

AOD-9604 is used in research to investigate fat metabolism, energy balance, and adipose-tissue signaling in controlled laboratory models.

Scientific Background

Native human Growth Hormone contains 191 amino acids. Research identified that the 176–191 region plays a key role in:

• Fat breakdown (lipolysis)

• Inhibition of lipogenesis (fat formation)

• Metabolic regulation

AOD-9604 is a stabilized version of this fragment with enhanced biological activity and no direct GH or IGF-1–like growth effects.

In experimental systems, AOD-9604 may influence:

• Metabolic signaling pathways

• Adipocyte (fat cell) function

• Energy utilization

• Fatty-acid availability

Its selective mechanism makes it a valuable tool for studying fat metabolism independent of GH’s anabolic actions.

Research Areas of Interest

All information below is intended strictly for scientific, laboratory, and in-vitro research only.

1. Lipolysis & Fat-Breakdown Models

Researchers study AOD-9604 for potential roles in:

• Enhanced fat mobilization

• Stimulation of adipocyte lipolysis

• Reduction of lipid accumulation

2. Anti-Lipogenic Activity

Investigations include:

• Inhibition of new fat formation

• Influence on key enzymes involved in lipogenesis

3. Metabolic Regulation

AOD-9604 is commonly used to explore:

• Energy expenditure pathways

• Fatty-acid oxidation

• Cellular metabolism under different energy conditions

4. Comparative Studies with hGH

Since AOD-9604 does not activate IGF-1, it is compared with:

• Full-length Growth Hormone

• CJC-1295 + Ipamorelin combos

• 5-Amino-1MQ & mitochondrial peptides

5. Adipose Tissue Research

Used in models assessing:

• Adipocyte differentiation

• Hormonal regulation of fat cells

• Gene-expression patterns linked to metabolism

These findings come from preclinical and in-vitro studies and are not validated clinical outcomes.

Molecular Profile

• Peptide: AOD-9604

• Type: GH fragment (176–191) analogue

• Sequence Length: 15 amino acids

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Phe-Tyr-Ser-OH

• Molecular Weight: ~ 1,813 Da

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from heat, moisture, and light

• Reconstituted solutions should be used promptly or stored per laboratory protocol

• Avoid repeated freeze-thaw cycles

What the Research Shows About AOD-9604 & Cartilage

1. May Support Chondrocyte Activity (Lab Models)

Some in-vitro studies show that AOD-9604 can influence chondrocyte proliferation — the cells responsible for producing new cartilage matrix.

• Increased chondrocyte growth

• Improved collagen and proteoglycan expression (preclinical)

• Reduced inflammatory activity in joint-tissue models

This is entirely lab-based, not clinical.

Each 3ml vial is formulated with 10mg of highly purified (>99%) lyophilized AOD9604, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.