SS-31 10mg

SS-31 (also known as Elamipretide or MTP-131) is a synthetic tetrapeptide designed to target the inner mitochondrial membrane. It is widely studied for its potential roles in mitochondrial protection, cellular energy support, oxidative-stress reduction, and cardiolipin stabilization within laboratory and in-vitro research settings.

Due to its unique mitochondrial affinity, SS-31 has become a valuable tool in metabolic, cellular-aging, and bioenergetic research models.

Scientific Background

SS-31 is a cell-penetrating peptide engineered to selectively bind cardiolipin, a phospholipid essential for mitochondrial structure and function. By interacting with cardiolipin, SS-31 may help:

• Enhance electron-transport chain efficiency

• Reduce reactive oxygen species (ROS)

• Support ATP production

• Protect mitochondria under stress conditions

• Improve mitochondrial membrane integrity

This targeted activity distinguishes SS-31 from most peptides that do not naturally localize to mitochondria.

Research Areas of Interest

All information below is intended strictly for laboratory, scientific, and in-vitro research only.

1. Mitochondrial Function & Energy Production

SS-31 is frequently studied for:

• Improving mitochondrial respiration

• Supporting ATP synthesis

• Enhancing electron transport efficiency

2. Oxidative Stress Models

Research indicates potential effects on:

• Reduction of reactive oxygen species (ROS)

• Protection during oxidative damage

• Stabilization of mitochondrial membranes

3. Cellular Aging Research

Because mitochondrial decline is a hallmark of aging, SS-31 is used in studies investigating:

• Age-related mitochondrial dysfunction

• Cellular stress response

• Decline in bioenergetics

4. Cardiac & Skeletal Muscle Investigations

High-energy tissues such as heart and muscle are common areas of focus:

• Mitochondrial support during metabolic stress

• Cellular resilience during injury models

• Potential restoration of mitochondrial efficiency

5. Neuroprotective Pathway Research

SS-31 is of interest in early studies exploring:

• Neuronal mitochondrial protection

• Stress-induced mitochondrial dysfunction

• Potential maintenance of neuronal energy balance

These findings are based on preclinical and in-vitro research, not validated human clinical outcomes.

Molecular Profile

• Peptide: SS-31 (Elamipretide / MTP-131)

• Sequence: D-Arg-Dmt-Lys-Phe-NH₂

  • Dmt = 2’,6’-dimethyltyrosine

• Type: Tetrapeptide

• Category: Mitochondria-Targeted Peptide (MTP)

• Molecular Weight: ~ 639 Da

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from light, heat, and humidity

• Reconstituted solutions should be used promptly or stored per lab protocols

• Avoid repeated freeze-thaw cycles

  Each 3ml vial is formulated with 5mg of highly purified (>99%) lyophilized SS-31, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.