Ipamorelin 5mg Nasal Spray: 100mcg per Spray

Ipamorelin is a synthetic pentapeptide and a highly selective growth hormone secretagogue (GHS) studied for its ability to stimulate the release of endogenous growth hormone through activation of the ghrelin (GHSR-1a) receptor. Known for its clean, targeted mechanism and low off-target activity, Ipamorelin is used in research examining GH signaling, endocrine pathways, and pituitary function.

It is one of the most receptor-specific GH secretagogues in modern peptide research.

Scientific Background

Ipamorelin belongs to the class of GHRP (Growth Hormone–Releasing Peptides) but is distinguished by its exceptional receptor selectivity. Unlike older GHRPs (such as GHRP-2 and GHRP-6), Ipamorelin shows minimal interaction with:

• Cortisol pathways

• Prolactin

• Hunger-related ghrelin effects

In preclinical research, Ipamorelin is associated with:

• Activation of GHSR-1a receptors in pituitary cells

• Pulsatile GH release

• Minimal impact on ACTH or prolactin levels

• Highly targeted endocrine signaling

This makes it a valuable molecule for growth hormone and pituitary-model studies.

Research Areas of Interest

All information below is intended strictly for laboratory, scientific, and in-vitro research only.

1. Growth Hormone Secretagogue Research

Ipamorelin is studied for:

• GH pulse stimulation

• Pituitary receptor activation

• Interactions with GHRH analogues (e.g., CJC-1295, Sermorelin)

2. Endocrine System Investigations

Research explores:

• Hormonal feedback loops

• IGF-1 signaling pathways

• Cross-talk between ghrelin and GH receptors

3. Pituitary & Hypothalamic Models

Ipamorelin is used to examine:

• Pituitary cell response

• Ghrelin receptor kinetics

• GH secretion dynamics

4. Comparative Studies with Other GHRPs

Ipamorelin is frequently compared to:

• GHRP-2

• GHRP-6

• Hexarelin

• MK-677

It is often evaluated for its cleaner receptor profile and lower off-target hormonal activity.

5. In-Vitro & Preclinical Physiology Research

Researchers investigate potential effects on:

• Endocrine cell signaling

• Energy regulation pathways

• GH–dependent molecular processes

All findings are from preclinical or in-vitro models only, not validated clinical outcomes.

Molecular Profile

• Peptide: Ipamorelin

• Type: GH Secretagogue, GHSR-1a Agonist

• Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂

  • Aib = aminoisobutyric acid

  • 2-Nal = 2-naphthylalanine

• Length: 5 amino acids (pentapeptide)

• Molecular Weight: ~ 711 Da

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from light, heat, and moisture

• Use reconstituted solutions promptly or store per lab protocol

• Avoid repeated freeze-thaw cycles

Each 3ml vial is formulated with 5mg of highly purified (>99%) lyophilized Ipamorelin, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.