Sermorelin 5mg: GHRH Peptide

Sermorelin (also known as GRF 1-29) is a synthetic 29-amino-acid peptide fragment of Growth Hormone–Releasing Hormone (GHRH). It is studied for its ability to selectively stimulate the pituitary GHRH receptor, making it a key molecule in research related to growth hormone signaling, endocrine regulation, and hypothalamic–pituitary axis function.

As a shorter, stable analogue of naturally occurring GHRH, Sermorelin provides a targeted tool for evaluating growth hormone pathways in laboratory settings.

Scientific Background

Native GHRH is a 44-amino-acid peptide. Sermorelin represents the biologically active first 29 amino acids, which retain full receptor-binding and functional activity.

In research environments, Sermorelin is associated with:

• Activation of GHRH receptors in pituitary cells

• Promotion of pulsatile growth hormone release

• Regulation of IGF-1 signaling pathways

• Study of endocrine feedback loops

• Exploration of hypothalamic–pituitary interactions

Because it mimics natural GHRH activity while being smaller and more stable, Sermorelin is widely used in both in-vitro and in-vivo growth hormone–related studies.

Research Areas of Interest

All information below is intended strictly for laboratory, scientific, and in-vitro research only.

1. Growth Hormone Pathway Research

Sermorelin is used to explore:

• GH pulsatility

• Pituitary receptor activation

• Signaling cascades linked to IGF-1 expression

2. Endocrine & Metabolic Models

Researchers evaluate potential roles in:

• Energy-regulation pathways

• Hormonal feedback systems

• Anabolic and metabolic signaling

3. Cellular & Genetic Research

GHRH receptor activation is studied for its effects on:

• Cell proliferation

• Gene transcription

• Peptide–receptor kinetics

4. Comparative Incretin & Peptide Studies

Sermorelin is often compared with or studied alongside:

• CJC-1295

• Ipamorelin

• GHRP-2 and GHRP-6

• Tesamorelin

• Endogenous GHRH

5. Hypothalamic–Pituitary Axis Models

Due to its targeted mechanism, Sermorelin is used to investigate:

• Pituitary stimulation

• GH secretory behavior

• Hormonal communication between brain and endocrine tissues

These findings are based on preliminary, preclinical, and in-vitro studies — not validated clinical outcomes.

Molecular Profile

• Peptide: Sermorelin (GRF 1-29)

• Sequence Length: 29 amino acids

• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from heat, moisture, and light

• Reconstituted solutions should be used promptly or stored per laboratory guidelines

• Avoid repeated freeze-thaw cycles

  Each 3ml vial is formulated with 5mg of highly purified (>99%) lyophilized Sermorelin, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.