KPV 10mg: Anti-Inflammatory Peptide

KPV (Lys-Pro-Val) is a biologically active tripeptide fragment derived from the α-MSH hormone and is widely studied for its potential interaction with inflammation pathways, immune signaling, and epithelial barrier function. Research interest in KPV continues to grow due to its selective, targeted activity and its ability to influence models related to skin health, gut integrity, and localized inflammatory responses.

Each vial contains sterile, research-grade KPV optimized for controlled scientific investigation, Because of its small size and high stability, KPV is often used to explore inflammation-related pathways across multiple tissues, including skin, gut, and immune systems.

Scientific Background

KPV is a naturally occurring fragment of α-MSH, a hormone involved in pigmentation, immune signaling, and the body’s anti-inflammatory response.

In laboratory studies, KPV is associated with:

• Downregulation of pro-inflammatory cytokines

• Modulation of NF-κB pathways

• Reduction of oxidative stress

• Support of epithelial barrier integrity

• Interaction with melanocortin receptors

Its simplicity (3 amino acids) and strong activity make it valuable for targeted inflammation research.

Research Areas of Interest

All information below is intended strictly for scientific, laboratory, and in-vitro research only.

1. Anti-Inflammatory Pathways

KPV has been extensively studied for potential roles in:

• Reducing inflammatory cytokines (TNF-α, IL-6, IL-1β)

• Modulating immune responses

• Suppressing excess NF-κB activation

2. Gastrointestinal / Intestinal Models

Research explores possible effects on:

• Intestinal barrier support

• Epithelial cell protection

• Inflammatory bowel disease (IBD) models

• Gut mucosal stability

3. Skin & Wound Research

In dermatological research systems, KPV may influence:

• Local inflammatory response

• Wound microenvironment

• Skin-barrier resilience

4. Immune Modulation

KPV is used in immune-cell research to examine:

• Anti-inflammatory immune signaling

• T-cell activity

• Macrophage regulation

5. Combination Research

KPV is often studied alongside other peptides such as BPC-157, GHK-Cu, TB-500, and LL-37 to evaluate multi-pathway interactions.

These findings come from preclinical and in-vitro studies, not verified clinical outcomes.

Molecular Profile

• Peptide: KPV

• Type: Tri-peptide (Lys-Pro-Val)

• Sequence: KPV

• Molecular Weight: ~ 356 Da

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from heat, moisture, and light

• Reconstituted solutions should be used promptly or stored per lab protocol

• Avoid repeated freeze-thaw cycle

  Each 3ml vial is formulated with 10mg of highly purified (>99%) lyophilized KPV, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.