Semax 5mg: Nootropic Peptide

Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment (adrenocorticotropic hormone). It is widely studied for its potential effects on neuroprotection, cognitive pathways, BDNF expression, stress modulation, and central nervous system regulation in laboratory and in-vitro research models.

Because it does not affect cortisol levels like full-length ACTH, Semax provides a targeted neuroactive research profilewithout stimulating adrenal hormone production.

Scientific Background

Semax is a modified fragment of ACTH designed to retain neurological activity while removing its endocrine/adrenal-stimulating effects.
It contains a Pro-Gly-Pro extension added for increased stability and bioactivity.

In preclinical studies, Semax has been associated with:

• Upregulation of BDNF (Brain-Derived Neurotrophic Factor)

• Modulation of neurotransmitter systems (dopaminergic & serotonergic)

• Neuroprotective signaling under stress or hypoxic conditions

• Cognitive processing & memory-related pathways

• Stress-response and adaptive neural activity

These characteristics make Semax a key peptide in neurobiology and behavioral research.

Research Areas of Interest

All information below is for scientific, laboratory, and in-vitro research only.

1. Neuroprotection & Neural Resilience

Semax is used to investigate:

• Protective responses in neural cells

• Antioxidant-related pathways

• Stress-induced neuronal changes

2. Cognitive & Memory Pathways

Studies evaluate potential effects on:

• Learning-associated signaling

• Memory consolidation

• Attention-related neural circuits

3. BDNF & Neurotrophic Regulation

Semax is widely studied for its ability to influence:

• BDNF expression

• TrkB-related pathways

• Neuroplasticity mechanisms

4. Stress Response & Homeostasis

Researchers explore:

• Modulation of the hypothalamic–pituitary–adrenal (HPA) axis

• Adaptation under psychological or metabolic stress

• CNS regulatory responses

5. Dopamine & Serotonin Research

Semax is often used in studies involving:

• Monoamine regulation

• Neuromodulatory signaling

• Behavioral adaptation markers

In these research settings, Semax has demonstrated measurable effects on neurological activity—such as improved performance in learning tasks, enhanced memory formation in animal models, and modulation of neurochemical pathways related to focus and mood.

All findings derive from preclinical and in-vitro models, not clinical outcomes.

Molecular Profile

• Peptide: Semax

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro

• Type: ACTH(4-10)–derived heptapeptide analogue

• Length: 7 amino acids

• Molecular Weight: ~867.9 Da

• Form: Lyophilized powder

• Purity: ≥ 98% (HPLC tested)

Semax does not stimulate cortisol or adrenal glands due to removal of ACTH endocrine domains.

Storage & Stability

• Store lyophilized peptide at –20°C

• Protect from moisture, heat, and light

• Use reconstituted solution promptly or store as per laboratory protocol

• Avoid repeated freeze–thaw cycles

Each 3ml vial is formulated with 5mg of highly purified (>99%) lyophilized Semax, produced in sterile environments that meet research-grade standards. Prime Peptides validates every batch through third-party laboratory testing to ensure exact molecular composition, stable peptide structure, and consistent results suitable for a wide range of experimental designs.